A Clinical Study on Anti-wrinkle Efficacy of a Cosmetics Containing Oligoarginine Conjugation of Palmitoyl-GHK peptide for Skin Penetrating

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Su-In Park, Soo Hyeon Heo, Jinseo Lee, Hoon Cha, Moon Sam Shin

Abstract

In this study, Arg 4 (R4) was conjugated with Pal-GHK to get palmitoyl heptapeptide, Pal-GHK‐R4 and wrinkle improvement clinical trials of cosmetics containing Pal-GHK‐R4 were conducted. As a result of total 21 subjects used the test products 4 weeks use on the face area; 1) measurement results of crow’s feet after 2 and 4 weeks of test products use, analysis value of crow’s feet statistically significantly decreased after 2 and 4 weeks of test products use compared to before use of products (p<0.05); 2) measurement results of skin moisturization after 2 and 4 weeks test products use, measured value of skin moisture content statistically significantly increased after 2 and 4 weeks use compared to before use of products (p<0.05); 3) measurement results of TEWL after 2 and 4 weeks use, measured value of TEWL statistically significantly decreased after 2 and 4 weeks use compared to before use of product(p<0.05); 4) there was no skin adverse event reported after using the products during the study period. Therefore, the test products containing both wrinkle improving and skin penetrating peptides, Pal-GHK‐R4 are considered to have beneficial effects on improvement of skin wrinkle, moisturization, transepidermal water loss(TEWL) after 2 and 4 weeks use of test product.

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How to Cite
Jinseo Lee, Hoon Cha, Moon Sam Shin, S.-I. P. S. H. H. . (2021). A Clinical Study on Anti-wrinkle Efficacy of a Cosmetics Containing Oligoarginine Conjugation of Palmitoyl-GHK peptide for Skin Penetrating. Turkish Journal of Computer and Mathematics Education (TURCOMAT), 12(5), 401–406. Retrieved from https://turcomat.org/index.php/turkbilmat/article/view/974
Section
Research Articles