ROLE OF MATRIX METALLOPROTEINASES (MMPS) IN COLORECTAL CANCER (CRC): REGULATION AND THERAPEUTIC INTERVENTIONS
Main Article Content
Abstract
The matrix metalloproteinases (MMPs) comprises of proteases that are well regulated with
their endogenous anti-proteinases in many physiological processes with the right expression and
stoichiometry. The dysregulation of that metalloproteinases and anti-proteinases play important role in several pathological processes and more viciously in tumour progression and the metastasis. It has been shown by investigators that matrix metalloproteinases (MMPs) play important role in colorectal cancer (CRC) invasion and metastasis. The MMPs able to degrade and/or activate proteins, that play crucial role in tumour initiation, progression and metastases, suggesting that proper regulation and/or management of MMPs during colorectal cancer would be the possible diagnostic, prognostic and therapeutic targets of patients of CRC. Therefore, MMPs have been unanimously considered as the advanced and one of the therapeutic strategies focusing on mainly down regulating or blocking these proteinases by several natural as well as synthetic inhibitors. In fact, many clinical trials by researchers using MMP inhibitors were going on to manage this disease by so many different and efficient ways. Based on this evidence, the pharmaceutical industry produced several well tolerated, active MMP inhibitors (MMPIs) which demonstrated efficacy in different CRC models too.
Downloads
Metrics
Article Details
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
