A New-fangled Corona virus coupled with Human Respiratory and AI in COVID-19 Discovery

Recently a very strange time to fight with invisible enemy. The Corona virus ailment 2019 also known as COVID19 outburst, which emerged from Wuhan, the Hubei Province, China, had broaden to all the regions of China and 28 additional countries. Corona viruses are a group of viruses with non segmented, single stranded and positive–sense RNA genomes. Corona viruses is also popular to contaminate human hosts and effect respiratory disease like brutal SARS-CoV (Acute Respiratory Syndrome Corona virus) and MERS-CoV (Middle East Respiratory Syndrome Corona virus). In this paper we discussed on detail analysis of COVID-19 disease.


Introduction
The name Corona virus is derived from the Latin word corona, meaning "crown" or "halo" because the virus has "crown-like spikes on their surface". Corona viruses are a ancestors of viruses which start from the widespread cold to MERS corona virus, that is available in MERS (Middle East Respiratory Syndrome) corona virus and SARS (Severe Acute Respiratory Syndrome) corona virus. Corona viruses are mostly found to be circulated in animals but few of these corona viruses have the potential of transit from animals and humans and vice-versa. Corona viruses were primarily discovered among chicks in year 1930 when an finely tuned respiratory contamination of domestic chickens was exposed to be caused by Infectious Bronchitis Virus (IBV). Human corona viruses were discovered in the 1960s.
In today's era due to the emerging infectious disease there is a huge threat in public about these diseases, like SARS (Severe Acute Respiratory Syndrome) and Zika virus disease. In December 2019, SARS-CoV (Severe Acute Respiratory Syndrome β-Corona virus) was detected in Wuhan, China. It was initially named as 2019-nCoV (2019-Novel Corona virus) on 12th January 2020 by World Health Organization (WHO) and later WHO officially named the disease as COVID-19(Corona virus Disease 2019). On 11th February 2020, according to the survey it has also been found that there is a close genetic relationship between SARS-CoV and SARS-CoV-2.
There are many species of virus found in Bats, which are also known as natural resource of viruses such as Nipah, Ebola, Rabies, Hendra and Marburg. α-CoV(Alpha-CoV) and β-CoV(beta-CoV) are also been detected in bats in Asian and African countries and some parts of America. CoV's are single-stranded, optimistic sagacity RNA viruses with a comparatively large genome size 26 to 32 kb. They are classified into four generations namely α−/β−/γ−/δ-CoV. From this α-and β-CoV are highly capable of infecting mammals, while γ-and δ-CoV primarily have a propensity to contaminate birds. The transmission of SARS-CoV-2 mainly takes place from one human being to another i.e. among family unit, relations and acquaintances that came into contact with patients.

How Corona virus can be spread?
There are three major symptoms how a Corona virus is spread: 1. The first major transmission of Corona virus is when a person is coughing and sneezing without covering his/her mouth/nose and spread the droplets in the air. 2. The second reason is when Handshaking or touching an infected person. 3. The third reason is when a person touches a plane or an entity which consist of droplets of disease and after the person touches his/her eyes, nose or mouth. National Institutes of Health (NIH) provides the different teams of public those who are at high risk due to COVID-19. In this people from age group of 60 and above, children's of age group 0-10 and pregnant ladies are there; also people who are underlying any medical conditions are also prone to such viruses.

Is there a cure for corona virus?
There is no specific treatment available till date, but doctors are using the existing drugs for viruses such as Ebola, malaria and HIV. Development of a vaccine is in progress many scientists are working on it, but it is unlikely to be available in next year.
Phenotype and Genotype of Covid-19 Corona viruses owns the major genomes (26.4e31.7 kb) out of all available RNA virus, with G þ C stuffing changeable from 32% to 43%. changeable figures of tiny ORFs are there stuck between the variety of sealed genes (envelope, membrane, ORF1a/b, spike, and nucleo capsid). The viral genome also has some typical features, counting a sole N-terminal portion inside the spear protein. Genes for the most important structural proteins in each corona virus take place in the 50e30 classify as S, E, M, and N [7] (Fig. 2).
A distinctive CoV includes a smallest count of six ORFs in its genome. Apart from Gamma corona virus with the aim of lakes nsp1, the primary ORFs (ORF1a/b), with reference to two-thirds from the entire genome measurement lengthwise, encode 16 nsps (nsp1-16). ORF1a and ORF1b hold a frame shift amongst that produce two polypeptides: pp1a and pp1ab.  Difference between SARS-COVID19, SARS-CoV, and MERS-CoV, these 50UTR, 30UTR are mixed up in inter and intra-molecular exchanges which are very significant from the functionally perspective for RNAeRNA exchanges and for fastening of viral and cellular proteins. [4] Pb1ab is the foremost ORF of the entire genome measurement lengthwise programming non-structural proteins by means of size of 29844bp (7096aa) for COVID-19, 29751bp (7073aa) in SARS-CoV and 30119bp (7078) MERS-CoV, correspondingly. Also when we are comparing the spike protein of all the corona viruses particularly for COVID-19 it is 1273aa, SARS-CoV it is 21493aa, and 1270aa for MERS-CoV. Hereditarily, COVID-19 was found not as much of same as of SARS-CoV (around 79%) and MERS-CoV (around 50%). The understanding of envelope protein(E), nucleocapsid protein (N), and membrane protein (M) among these three corona viruses is different as shown in Fig. 3

Literature Survey
Fan Wu et. al. the study has been carried out on a model of bronchoalveolar lavage fluid out of the 41year old patient recognized novel RNA virus strain commencing the relations Coronaviridae, that is elected here 'WH-Human1' coronavirus. Phylogenetic examination of the whole viral genome (29,903 nucleotides) discovered that the virus was mainly strongly associated (89.1% nucleotide similarity) to a cluster of SARS-like corona viruses. This disease damage was nominated as WH-Human 1 coronavirus (WHCV). To conclude the evolutionary associations sandwiched between WHCV and beforehand recognized corona viruses, phylogenetic trees was predictable on the foundation of the nucleotide sequence of the whole-genome sequences, the non-structural protein genes ORF1a and ORF1b, and the chief structural proteins programmed by the S, E, M and N genes. For enhanced accepting the latent of WHCV to contaminate humans, the receptor-binding domain (RBD) of its spike protein was differentiated with others like SARS-CoVs and bat SARS-like CoVs. The RBD sequence of WHCV were further strongly correlated to that of SARS-CoVs.
Shrikrushna Subhash Unhale et. al. as we include witness the coming out of two zoonotic, exceedingly pathogenic HCoVs: severe acute respiratory set of symptoms corona virus (SARS-CoV) and Middle East respiratory set of symptoms corona virus (MERS-CoV). Reproduction of HCoV is synchronized by a variety of host factor and induces severe alteration in cellular organization and functioning. In this paper authors has reviewed all the information available related to corona virus including types, life cycle of virus, transmission, symptoms that can be observed, how it can be Diagnosed, available Treatment, and Prevention methods. Statistics on region wise count of cases and death count across all over the world and Indian region wise statistics is also present.
Yan-Rong Guo et. al. with the most recent investigation development of the epidemiology, pathogenesis, and medical distinctiveness of COVID19, and with the existing knowledge of SARS-CoV-2 the authors summarized the information as above: Initially, the rising pneumonia, COVID19, caused by SARS-CoV-2, exhibit muscular contamination but a smaller amount virulence, compared to SARS and MERS, in requisites of morbidity and mortality. Initiating from pool of bats and unidentified transitional hosts, SARS-CoV-2 binds to ACE2 with towering resemblance as a virus receptor to contaminate humans. Secondly, the vulnerable inhabitants involves the old and citizens with convinced original medicinal circumstances, which require added concentration and care. Thirdly, the underneath treatment, collectively with strong antiviral drugs, such as remdesivir, chloroquine, or lopinavir/ritonavir, were performed with explicit results on treating COVID19 patients. Lifang Li et. al. [10] during this pandemic situation public use societal medium to get hold of and switch over different types of information at a notable and exceptional level. As the on-spot data is important for the civic and establishment to answer to the outbreak, it became extremely vital to recognize such situational data and to comprehend how it is life form propagated on societal medium. This paper tries to plug this opening by harnessing Weibo data tool and NLP techniques and distinguished the COVID-19-related data in seven different types of situational data like, concern and recommendation, fatalities and harm contributions of money, commodities, or services, people absent, found, or seen.
Wen-Hua Kong et. al. job has been carried out to re-analyse 640 throat swabs composed from patients in Wuhan with influenza-like-illness from 6 October 2019 to 21 January 2020 and bring into being that 9 of the 640 throat swabs were positive for SARS-CoV-2 RNA by quantitative PCR, signifying the public show of SARS-CoV2 in Wuhan in the beginning January 2020. The discovery of SARS CoV-2 cases amongst confined patients with ILI suggests that the public spread was recognized in Wuhan in the early hours in January. Relating to the current outbreaks episode on the Diamond Princess Cruise ship and Daequ, South Korea, the author suggested the intensification the pathogen observation of ILI cases in all cities facing the hazard of SARS-CoV-2 the public spread.

Michael Dub´e et. al. the Graph Evolution Tool (GET) was build to produce individual get in touch with
network on behalf of who can contaminate whom surrounded by a community. GET is prolonged upon to reproduce communities which comprise 512 individuals in up to eight districts, Originally infecting one person in one region and dispersion all the way through a society. Said Nadeem as this deadly disease is incredibly new and incredibly less methodical matter is obtainable on the subject, a variety of paid journals and companies are contributing by giving free resources in print about the Coronavirus. In this paper, all the articles about Coronavirus that are unreservedly provided by a range of journals and companies in the region of the planet are discussed. This examination is also unbolt to update so if any free starting place can be further added or modernized at this point.

Analysis of Corona Virus Diseases
Below Table 1. shows that analysis of coronavirus diseases.

AI in covid-19 detection
As the COVID-19 epidemic carry on to boost transversely the sphere, Industries and researchers are finding many ways to utilize AI as a technique of solving the challenge of the virus. At this point presently a quantity of the projects by means of AI to that deal with the corona-virus epidemic.
AI system were considered to be amongst the initial to notice so as to the corona-virus outburst, reverse while it was immobile imperfect to a small area of the Chinese city of Wuhan, possibly will turn out to be a full-on international epidemic. It's consideration that AI-driven Health-Map, which is associated with the Boston Children's Hospital, Collected the improving cluster of mysterious pneumonia belongings soon previous to human being researchers, even though it only rank the outbreak's importance as medium.
An Assistant professor from the department of psychology, Stanford University named Johannes Eichstaedt, had been investigating Twitter posts to guess how COVID-19, and updates are brought to the way how we live our lives, is upsetting our psychological fitness. By means of AI-driven text examination, Eichstaedt queried over two million tweets hash tagged with COVID-related stipulations for the period of February and March, and pooled it with further datasets on applicable factors counting the no. of cases, deaths, demographics and other, to light the virus effects on mental healthiness.
Canadian startup Darwin AI has urbanized a neural network which could monitor X-rays for signs of COVID-19 contagion. When using swabs of patients is default for testing for coronavirus, analyzing chest Xrays might tender a choice to hospitals that does not have an adequate amount of workforce or testing kits to course all of the patients rapidly.
A machine-learning community owned by Google named Kaggle is scenery to no. of COVID19 associated challenge to the members of family, together with fore-casting the no. of cases and fatalities by city as a means of guessing accurately why a variety of spaces are beat inferior than others. Deep Mind, the AI appendage of Google's parent corporation Alphabet, is accessing data on genomes to forecast organisms protein organization, potentially flaking glow on which drugs could work adjacent to COVID19.
No. of research projects are making use of AI to be familiar with drugs which were urbanized so as to struggle further disease although which could now be re-purposed to acquire on corona-virus. By understanding the molecular set of connections of lively drugs with AI, companies want to recognize which ones may disturb the pattern in COVID19 works.

Experimental Results
We have analyzed Covid19 dataset of India which is available on Kaggle. The dataset which is used here is collected over period of 30 January 2020 to 16 may 2020.    Here it shows that the lockdown declared in the country worked well to control the spread of Covid-19 and the result also shows that the recovery of patient in India is also good.

Conclusion
In this paper we did the detailed analysis of corona virus i.e. COVID-19 with their symptoms and how to take cure. Addressing the different challenges of the viruses by using Artificial Intelligence as a method. AI system were found to be amongst the initial to notice with the aim of corona virus outburst. In this paper we analyzed COVID-19 dataset of India which is available on Kaggle. In India lockdown has been declared to control the spread of COVID-19 and the outcome of this shows that the recovery rate of patients is good.